Objective The association ns between prediabetes and androgens have already been rarely reported, especially in Chinese men. prevalence of prediabetes and diabetes persisted statistically significant, especially in the elderly with prediabetes (all for pattern <0.05). Conclusions Serum androgen was inversely associated with prediabetes and diabetes in Chinese men. Low serum SHBG was the most relevant factor for prediabetes and diabetes. Whether it is an independent predictor for incident prediabetes in Chinese men needs further explorations. Introduction Type 2 diabetes mellitus (T2DM), the major component of diabetes mellitus, is usually a highly prevalent complex chronic disease in China, where the age-standardized prevalence has rapidly increased from 9.7% in 2008 to 11.6% in 2010 2010 [1]. However, unlike the USA, which has the similar high rate of T2DM as well as the high rate of obesity, China has much lower rate of overweight and obesity [2, 3]. On the other hand, the phenomena that both serum testosterone levels of young Chinese men and the rates of hormone related cancers in older Chinese men are significantly lower than those of Western populations [4], suggesting that low testosterone may be one of the potential risk factors adding to the prevalence of T2DM in China apart from overweight and weight problems. Previous epidemiological research show that diabetes is certainly connected with testosterone insufficiency in male populations. It's been reported that around 25% to 40% of diabetic guys have got low testosterone amounts [5, 6], aswell as male sufferers with hypogonadism, such as for example Klinefelters syndrome, have got an increased occurrence of diabetes [7]. Serum total testosterone (TT) comprises free of charge testosterone Glucosamine sulfate supplier (Foot) (2C3%), Glucosamine sulfate supplier albumin-bound (20C40%), and sex hormone-binding globulin (SHBG) destined testosterone (60C80%). Nevertheless, the organizations between serum TT, Foot and SHBG and T2DM in male populations weren't identical in previous investigations [6, 8C12]. Prediabetes, the stage between normal glucose metabolism and diabetes, is characterized by -cell dysfunction and increased insulin resistance [13]. The prevalence of prediabetes in China has amazingly increased to 50.1% in 2010 2010 [1]. Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are used in the diagnosis of prediabetes in most countries, while the glycated hemoglobin A1c (HbA1c) of 5.7% to 6.4% is considered as a new diagnostic criteria by the American Diabetes Association (ADA) recently [14]. Prediabetes recognized by IFG, IGT, or the new HbA1c criteria may be caused by different mechanisms and represent different features of metabolic derangement [15, 16]. However, few studies have investigated the associations between androgens and prediabetes in men, especially in Chinese male populations [17]. The objective of the present study was to investigate whether serum TT, FT or SHBG levels was associated with the prevalence of prediabetes diagnosed with new ADA criteria in male populations from your SPECT-China study and then assess that which kind of androgens was the most related factor for prediabetes. Materials and Methods Study design and subjectsSPECT-China study SPECT-China is usually a population-based cross-sectional survey on prevalence of metabolic diseases and risk factors in East China, which is made up of Shanghai TSPAN31 and 7 provinces with a population of approximately 395 million in 2011, accounting Glucosamine sulfate supplier for 29.2% of people in China. 99.5% of residents are Han Chinese. Registration number is usually ChiCTR-ECS-14005052, www.chictr.org. This study was performed in Shanghai, Zhejiang and Jiangxi Province from February to June 2014. Adults aged 18 years old and above who were Chinese citizens and lived in current residence for 6 months or longer were recruited for this study. Those who experienced acute illness, severe communication problems or refused to participate in the study Glucosamine sulfate supplier were excluded. A total of 7200 people participated in this investigation. The participants who were more youthful than 18 years old (n = 6) or experienced missing lab results.